Assay Detail
Functional
CHEMBL1613898
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: E3 Ligase dose-response_384. (Class of assay: confirmatory) [Related pubchem assays: 1444 (E3 Ligase_dose response), 1442 (E3 Ligase_dose response), 1230 (E3 Ligase HTS_1536)]
167
Total Activities
167
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Category | confirmatory |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 167 | 5.53 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1443819 | — | — | 1 | 8.68 |
| CHEMBL1442077 | — | — | 1 | 8.00 |
| CHEMBL1493936 | — | — | 1 | 8.00 |
| CHEMBL1444103 | — | — | 1 | 8.00 |
| CHEMBL3209768 | — | — | 1 | 8.00 |
| CHEMBL3197200 | — | — | 1 | 7.70 |
| CHEMBL1574026 | — | — | 1 | 7.52 |
| CHEMBL1531114 | — | — | 1 | 7.40 |
| CHEMBL1390833 | — | — | 1 | 7.16 |
| CHEMBL1393655 | — | — | 1 | 7.05 |
| CHEMBL1573529 | — | — | 1 | 7.00 |
| CHEMBL1550485 | — | — | 1 | 6.89 |
| CHEMBL1460750 | — | — | 1 | 6.80 |
| CHEMBL1579035 | — | — | 1 | 6.77 |
| CHEMBL120563 | THIRAM | 2.0 | 1 | 6.75 |
| CHEMBL1494074 | — | — | 1 | 6.72 |
| CHEMBL1391781 | — | — | 1 | 6.66 |
| CHEMBL1463713 | — | — | 1 | 6.62 |
| CHEMBL2004241 | — | — | 1 | 6.58 |
| CHEMBL1546843 | — | — | 1 | 6.57 |
| CHEMBL1546972 | — | — | 1 | 6.54 |
| CHEMBL1459746 | — | — | 1 | 6.42 |
| CHEMBL1321494 | — | — | 1 | 6.42 |
| CHEMBL1399821 | — | — | 1 | 6.41 |
| CHEMBL338474 | HELENALIN | — | 1 | 6.38 |
| CHEMBL1563867 | — | — | 1 | 6.28 |
| CHEMBL1492017 | — | — | 1 | 6.25 |
| CHEMBL1377737 | — | — | 1 | 6.25 |
| CHEMBL494255 | AROMATICIN | — | 1 | 6.23 |
| CHEMBL1494120 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1443819 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL1493936 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3209768 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1442077 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1444103 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3197200 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1574026 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1531114 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1390833 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1393655 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1573529 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1550485 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1460750 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1579035 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL120563 | THIRAM | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1494074 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1391781 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1463713 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2004241 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1546843 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1546972 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1321494 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1459746 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1399821 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL338474 | HELENALIN | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1563867 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL1377737 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL1492017 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL494255 | AROMATICIN | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1494120 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL1986619 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL1422950 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL1577840 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL1483654 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL1453212 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL1584440 | — | EC50 | = | 940.0 | nM | 6.03 |
| CHEMBL1344225 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL1433182 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1489368 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL3212629 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL1393825 | — | EC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL1564354 | — | EC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL1307185 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1387704 | — | EC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL1399698 | — | EC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL1510156 | — | EC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL1420393 | — | EC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL1500242 | — | EC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL1353015 | — | EC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL1599907 | — | EC50 | = | 1950.0 | nM | 5.71 |