Compound Detail
CHEMBL1433182
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Basic Information
| ChEMBL ID | CHEMBL1433182 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OGBFBWFKVLKSIE-BQYQJAHWSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
288.4
MW (Da)
3.72
ALogP
4
HBA
0
HBD
42.9
PSA (Ų)
0.37
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| E3 ubiquitin-protein ligase Mdm2 CHEMBL5023 | EC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Heat shock factor protein 1 CHEMBL5313 | EC50 | 4.83 | 4.83 | 14690.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| E3 ubiquitin-protein ligase Mdm2 | EC50 | = | 1000.0 | nM | 6.0 | PUBCHEM_BIOASSAY: E3 Ligase dose-response_384. (Class of assay: confirmatory) [R... | - |
| Heat shock factor protein 1 | EC50 | = | 14690.0 | nM | 4.83 | PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Retest to Identify Potentiators o... | - |
Data from ChEMBL 36 via Core Engine