Assay Detail
Binding
CHEMBL1614311
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: TR-FRET secondary assay for HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1. (Class of assay: confirmatory) [Related pubchem assays: 432 ]
185
Total Activities
175
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Category | confirmatory |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 185 | 5.37 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1272154 | — | — | 1 | 6.38 |
| CHEMBL1271764 | — | — | 2 | 6.30 |
| CHEMBL1531647 | — | — | 1 | 6.30 |
| CHEMBL1269202 | — | — | 1 | 6.27 |
| CHEMBL1272100 | — | — | 1 | 6.23 |
| CHEMBL1271495 | — | — | 1 | 6.14 |
| CHEMBL1519581 | — | — | 1 | 6.13 |
| CHEMBL1598121 | — | — | 1 | 6.11 |
| CHEMBL1323507 | — | — | 1 | 6.08 |
| CHEMBL1271994 | — | — | 1 | 6.01 |
| CHEMBL1272047 | — | — | 1 | 5.99 |
| CHEMBL1449204 | — | — | 2 | 5.93 |
| CHEMBL1271881 | — | — | 1 | 5.93 |
| CHEMBL1272048 | — | — | 1 | 5.90 |
| CHEMBL1271938 | — | — | 1 | 5.89 |
| CHEMBL1271993 | — | — | 1 | 5.89 |
| CHEMBL1328468 | — | — | 1 | 5.88 |
| CHEMBL1271766 | — | — | 1 | 5.87 |
| CHEMBL1271825 | — | — | 1 | 5.84 |
| CHEMBL1417970 | — | — | 2 | 5.84 |
| CHEMBL1484952 | — | — | 1 | 5.84 |
| CHEMBL1414442 | — | — | 1 | 5.82 |
| CHEMBL1272313 | — | — | 1 | 5.79 |
| CHEMBL1271765 | — | — | 1 | 5.78 |
| CHEMBL1331084 | — | — | 2 | 5.75 |
| CHEMBL1489550 | — | — | 1 | 5.71 |
| CHEMBL1272049 | — | — | 1 | 5.69 |
| CHEMBL1334163 | — | — | 1 | 5.68 |
| CHEMBL1271494 | — | — | 1 | 5.67 |
| CHEMBL1450886 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1272154 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1531647 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1271764 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1269202 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1271764 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL1272100 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1271495 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL1519581 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL1598121 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL1323507 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL1271994 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL1272047 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL1271881 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL1449204 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL1272048 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL1271938 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1271993 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL1328468 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL1271766 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL1417970 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL1484952 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL1271825 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL1414442 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL1272313 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL1271765 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL1331084 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL1489550 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL1272049 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL1334163 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL1271494 | — | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL1450886 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL1370758 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL1451200 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL1271823 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL1567695 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL1351212 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL1272099 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL1417970 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL1381644 | — | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL1329808 | — | IC50 | = | 3510.0 | nM | 5.46 |
| CHEMBL1360686 | — | IC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL1399711 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1330707 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL1271883 | — | IC50 | = | 3940.0 | nM | 5.41 |
| CHEMBL1272155 | — | IC50 | = | 4130.0 | nM | 5.38 |
| CHEMBL1346587 | — | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL1371774 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL1399711 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL1548175 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1364744 | — | IC50 | = | 4590.0 | nM | 5.34 |