Compound Detail
CHEMBL1271494
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O=C1C(Cl)=C(N2CCN(Cc3ccc4c(c3)OCO4)CC2)C(=O)N1c1ccc(Cl)c(Cl)c1
Basic Information
| ChEMBL ID | CHEMBL1271494 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NLKNWYMKDBRUKK-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
494.8
MW (Da)
3.86
ALogP
6
HBA
0
HBD
62.3
PSA (Ų)
0.60
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bcl-2-related protein A1 CHEMBL6044 | IC50 | 5.68 | 5.535 | 2100.0 | 2 |
| Bcl-2-related protein A1 CHEMBL1293239 | IC50 | 5.67 | 5.53 | 2140.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bcl-2-related protein A1 | IC50 | = | 2100.0 | nM | 5.68 | Inhibition of N-terminal FITC BH3 peptide binding to GST-tagged Bfl1 by time res... | 20933419 |
| Bcl-2-related protein A1 | IC50 | = | 2140.0 | nM | 5.67 | PUBCHEM_BIOASSAY: TR-FRET secondary assay for HTS discovery of chemical inhibito... | - |
| Bcl-2-related protein A1 | IC50 | = | 4100.0 | nM | 5.39 | Inhibition of N-terminal FITC BH3 peptide binding to GST-tagged Bfl1 by fluoresc... | 20933419 |
| Bcl-2-related protein A1 | IC50 | = | 4070.0 | nM | 5.39 | PUBCHEM_BIOASSAY: In Vitro Bfl-1 Dose Response Fluorescence Polarization Assay f... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20933419 | 10.1016/j.bmcl.2010.09.046 | Bcl-2-related protein A1 | 2 |
Data from ChEMBL 36 via Core Engine