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Assay Detail

CHEMBL1614359

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
PUBCHEM_BIOASSAY: Estrogen Receptor-beta Coactivator Binding Inhibitors Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 633 (Primary screen preceding this dose response confirmation assay.)]
ChEMBL ↗
390
Total Activities
390
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Category confirmatory
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Estrogen receptor beta (CHEMBL242) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 390 5.06 5.81

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1581750 — — 1 5.81
CHEMBL1375019 — — 1 5.77
CHEMBL1415426 — — 1 5.77
CHEMBL1577661 — — 1 5.72
CHEMBL1426947 — — 1 5.67
CHEMBL1337575 — — 1 5.66
CHEMBL1981243 — — 1 5.63
CHEMBL1431081 — — 1 5.63
CHEMBL1433062 — — 1 5.60
CHEMBL600336 — — 1 5.58
CHEMBL1542128 — — 1 5.58
CHEMBL1493891 — — 1 5.58
CHEMBL1431555 — — 1 5.58
CHEMBL1323006 — — 1 5.57
CHEMBL1569742 — — 1 5.57
CHEMBL1459655 — — 1 5.56
CHEMBL1377973 — — 1 5.56
CHEMBL1559715 — — 1 5.54
CHEMBL1480378 — — 1 5.51
CHEMBL1493034 — — 1 5.51
CHEMBL1468811 — — 1 5.50
CHEMBL1602678 — — 1 5.50
CHEMBL1507981 — — 1 5.49
CHEMBL1413557 — — 1 5.47
CHEMBL1547376 — — 1 5.47
CHEMBL1332007 — — 1 5.46
CHEMBL1531320 — — 1 5.45
CHEMBL1604955 — — 1 5.44
CHEMBL1578546 — — 1 5.42
CHEMBL1464539 — — 1 5.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1581750 — IC50 = 1562.5 nM 5.81
CHEMBL1375019 — IC50 = 1688.84 nM 5.77
CHEMBL1415426 — IC50 = 1699.18 nM 5.77
CHEMBL1577661 — IC50 = 1910.93 nM 5.72
CHEMBL1426947 — IC50 = 2151.52 nM 5.67
CHEMBL1337575 — IC50 = 2181.1 nM 5.66
CHEMBL1431081 — IC50 = 2324.07 nM 5.63
CHEMBL1981243 — IC50 = 2346.44 nM 5.63
CHEMBL1433062 — IC50 = 2490.5 nM 5.60
CHEMBL1493891 — IC50 = 2601.96 nM 5.58
CHEMBL1542128 — IC50 = 2651.11 nM 5.58
CHEMBL1431555 — IC50 = 2643.0 nM 5.58
CHEMBL600336 — IC50 = 2611.21 nM 5.58
CHEMBL1323006 — IC50 = 2715.87 nM 5.57
CHEMBL1569742 — IC50 = 2709.22 nM 5.57
CHEMBL1377973 — IC50 = 2730.07 nM 5.56
CHEMBL1459655 — IC50 = 2745.63 nM 5.56
CHEMBL1559715 — IC50 = 2919.45 nM 5.54
CHEMBL1493034 — IC50 = 3054.88 nM 5.51
CHEMBL1480378 — IC50 = 3094.22 nM 5.51
CHEMBL1468811 — IC50 = 3129.21 nM 5.50
CHEMBL1602678 — IC50 = 3200.05 nM 5.50
CHEMBL1507981 — IC50 = 3269.47 nM 5.49
CHEMBL1547376 — IC50 = 3365.82 nM 5.47
CHEMBL1413557 — IC50 = 3365.49 nM 5.47
CHEMBL1332007 — IC50 = 3505.3 nM 5.46
CHEMBL1531320 — IC50 = 3569.49 nM 5.45
CHEMBL1604955 — IC50 = 3624.79 nM 5.44
CHEMBL1578546 — IC50 = 3769.25 nM 5.42
CHEMBL1464539 — IC50 = 3780.18 nM 5.42
CHEMBL522990 — IC50 = 3845.62 nM 5.42
CHEMBL577758 — IC50 = 3874.41 nM 5.41
CHEMBL1342645 — IC50 = 3905.74 nM 5.41
CHEMBL1518838 — IC50 = 3873.39 nM 5.41
CHEMBL3189499 — IC50 = 4000.21 nM 5.40
CHEMBL1583667 — IC50 = 4104.36 nM 5.39
CHEMBL1541229 — IC50 = 4149.61 nM 5.38
CHEMBL1400764 — IC50 = 4510.28 nM 5.35
CHEMBL1504655 — IC50 = 4481.73 nM 5.35
CHEMBL1406018 — IC50 = 4649.82 nM 5.33
CHEMBL3199523 — IC50 = 4689.44 nM 5.33
CHEMBL240331 — IC50 = 4622.96 nM 5.33
CHEMBL1511693 — IC50 = 4879.31 nM 5.31
CHEMBL1310309 — IC50 = 5063.93 nM 5.30
CHEMBL1526851 — IC50 = 4957.17 nM 5.30
CHEMBL1328586 — IC50 = 5093.35 nM 5.29
CHEMBL1381306 — IC50 = 5308.76 nM 5.28
CHEMBL1580036 — IC50 = 5221.62 nM 5.28
CHEMBL1378869 — IC50 = 5481.52 nM 5.26
CHEMBL1448466 — IC50 = 5502.76 nM 5.26