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Compound Detail

CHEMBL1531320

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O=C(NCc1ccco1)c1cc2ccc(O)cc2oc1=O

Basic Information

ChEMBL ID CHEMBL1531320
Phase Preclinical
Structure Type MOL
InChI Key VSRQWJVOVDOTOW-UHFFFAOYSA-N
10
Targets
12
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

285.2
MW (Da)
2.02
ALogP
5
HBA
2
HBD
92.7
PSA (Ų)
0.72
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H11NO5
MW 285.25
Aromatic Rings 3
Heavy Atoms 21
NP-Likeness -0.81

Activity Summary

EC50 8 meas. best 6.54
IC50 4 meas. best 5.45

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Luciferin 4-monooxygenase
CHEMBL5567
EC50 6.54 6.54 288.0 1
Sphingosine 1-phosphate receptor 4
CHEMBL3230
EC50 5.74 5.74 1840.0 1
Unchecked
CHEMBL612545
EC50 5.74 5.74 1816.0 1
Sphingosine 1-phosphate receptor 2
CHEMBL2955
EC50 5.48 5.48 3284.0 1
Estrogen receptor beta
CHEMBL242
IC50 5.45 5.45 3569.5 1
Sphingosine 1-phosphate receptor 1
CHEMBL4333
EC50 5.3 5.3 5050.0 1
Streptokinase A
CHEMBL1293228
EC50 5.23 5.23 5855.0 1
Streptococcus sp. 'group A'
CHEMBL612389
EC50 5.1 5.1 7991.0 1
Unchecked
CHEMBL612545
IC50 4.99 4.97 10156.0 2
Streptococcus
CHEMBL612313
EC50 4.88 4.88 13320.0 1
Estrogen receptor
CHEMBL206
IC50 4.84 4.84 14298.5 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Luciferin 4-monooxygenase EC50 = 288.0 nM 6.54 PUBCHEM_BIOASSAY: Luminescence Biochemical Dose Response HTS to Identify Inhibit... -
Unchecked EC50 = 1816.0 nM 5.74 PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhi... -
Sphingosine 1-phosphate receptor 4 EC50 = 1840.0 nM 5.74 PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screenin... -
Sphingosine 1-phosphate receptor 2 EC50 = 3284.0 nM 5.48 PUBCHEM_BIOASSAY: Dose Response Cell Based Assay for Agonists of the S1P2 Recept... -
Estrogen receptor beta IC50 = 3569.49 nM 5.45 PUBCHEM_BIOASSAY: Estrogen Receptor-beta Coactivator Binding Inhibitors Dose Res... -
Sphingosine 1-phosphate receptor 1 EC50 = 5050.0 nM 5.3 PUBCHEM_BIOASSAY: Fluorescence-based counterscreen assay for S1P4 agonists: Cell... -
Streptokinase A EC50 = 5855.0 nM 5.23 PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden... -
Streptococcus sp. 'group A' EC50 = 7991.0 nM 5.1 PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden... -
Unchecked IC50 = 10156.0 nM 4.99 PubChem BioAssay. Counterscreen for inhibitors of LEDGF/p75-dependent integratio... -
Unchecked IC50 = 11341.0 nM 4.95 PubChem BioAssay. TR-FRET-based biochemical high throughput dose response assay ... -
Streptococcus EC50 = 13320.0 nM 4.88 PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Response HTS to Identify... -
Estrogen receptor IC50 = 14298.54 nM 4.84 PUBCHEM_BIOASSAY: Estrogen Receptor-alpha Coactivator Binding Inhibitors Dose Re... -

Data from ChEMBL 36 via Core Engine