Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1614192

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
PUBCHEM_BIOASSAY: Luminescence Biochemical Dose Response HTS to Identify Inhibitors of Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 1663 (Primary HTS), 1678 (Summary of Project)]
ChEMBL ↗
1584
Total Activities
1584
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Photinus pyralis
Category confirmatory
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Luciferin 4-monooxygenase (CHEMBL5567) ↗
Type SINGLE PROTEIN
Organism Photinus pyralis

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1584 5.63 6.98

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1387610 — — 1 6.98
CHEMBL1429789 — — 1 6.97
CHEMBL1489087 — — 1 6.92
CHEMBL405317 — — 1 6.91
CHEMBL1335571 — — 1 6.91
CHEMBL1328504 — — 1 6.89
CHEMBL1526174 — — 1 6.86
CHEMBL1527992 — — 1 6.83
CHEMBL1973921 — — 1 6.83
CHEMBL1985575 — — 1 6.82
CHEMBL1511219 — — 1 6.82
CHEMBL1459468 — — 1 6.80
CHEMBL3196469 — — 1 6.80
CHEMBL339304 — — 1 6.79
CHEMBL1480613 — — 1 6.76
CHEMBL3196809 — — 1 6.75
CHEMBL3194093 — — 1 6.74
CHEMBL3190132 — — 1 6.72
CHEMBL1480056 — — 1 6.72
CHEMBL1492001 — — 1 6.68
CHEMBL1543337 — — 1 6.68
CHEMBL1383312 — — 1 6.67
CHEMBL1360618 — — 1 6.65
CHEMBL1460869 — — 1 6.65
CHEMBL1430094 — — 1 6.62
CHEMBL3192393 — — 1 6.61
CHEMBL1492671 — — 1 6.60
CHEMBL1304770 — — 1 6.59
CHEMBL1523955 — — 1 6.59
CHEMBL1519965 — — 1 6.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1387610 — EC50 = 105.0 nM 6.98
CHEMBL1429789 — EC50 = 107.0 nM 6.97
CHEMBL1489087 — EC50 = 120.0 nM 6.92
CHEMBL1335571 — EC50 = 122.0 nM 6.91
CHEMBL405317 — EC50 = 122.0 nM 6.91
CHEMBL1328504 — EC50 = 129.0 nM 6.89
CHEMBL1526174 — EC50 = 137.0 nM 6.86
CHEMBL1973921 — EC50 = 149.0 nM 6.83
CHEMBL1527992 — EC50 = 149.0 nM 6.83
CHEMBL1511219 — EC50 = 152.0 nM 6.82
CHEMBL1985575 — EC50 = 151.0 nM 6.82
CHEMBL1459468 — EC50 = 159.0 nM 6.80
CHEMBL3196469 — EC50 = 158.0 nM 6.80
CHEMBL339304 — EC50 = 161.0 nM 6.79
CHEMBL1480613 — EC50 = 173.0 nM 6.76
CHEMBL3196809 — EC50 = 176.0 nM 6.75
CHEMBL3194093 — EC50 = 184.0 nM 6.74
CHEMBL3190132 — EC50 = 192.0 nM 6.72
CHEMBL1480056 — EC50 = 191.0 nM 6.72
CHEMBL1492001 — EC50 = 210.0 nM 6.68
CHEMBL1543337 — EC50 = 207.0 nM 6.68
CHEMBL1383312 — EC50 = 213.0 nM 6.67
CHEMBL1460869 — EC50 = 225.0 nM 6.65
CHEMBL1360618 — EC50 = 222.0 nM 6.65
CHEMBL1430094 — EC50 = 241.0 nM 6.62
CHEMBL3192393 — EC50 = 248.0 nM 6.61
CHEMBL1492671 — EC50 = 251.0 nM 6.60
CHEMBL1523955 — EC50 = 255.0 nM 6.59
CHEMBL1304770 — EC50 = 259.0 nM 6.59
CHEMBL1519965 — EC50 = 263.0 nM 6.58
CHEMBL408850 — EC50 = 263.0 nM 6.58
CHEMBL1545660 — EC50 = 276.0 nM 6.56
CHEMBL1573366 — EC50 = 283.0 nM 6.55
CHEMBL1531320 — EC50 = 288.0 nM 6.54
CHEMBL1986907 — EC50 = 286.0 nM 6.54
CHEMBL1524929 — EC50 = 296.0 nM 6.53
CHEMBL1996490 — EC50 = 295.0 nM 6.53
CHEMBL1574553 — EC50 = 299.0 nM 6.52
CHEMBL1524484 — EC50 = 311.0 nM 6.51
CHEMBL2007273 — EC50 = 316.0 nM 6.50
CHEMBL1387436 — EC50 = 324.0 nM 6.49
CHEMBL2003508 — EC50 = 329.0 nM 6.48
CHEMBL1332533 — EC50 = 349.0 nM 6.46
CHEMBL546344 — EC50 = 347.0 nM 6.46
CHEMBL1467431 — EC50 = 359.0 nM 6.45
CHEMBL1383281 — EC50 = 358.0 nM 6.45
CHEMBL1401676 — EC50 = 365.0 nM 6.44
CHEMBL3193424 — EC50 = 374.0 nM 6.43
CHEMBL1458038 — EC50 = 383.0 nM 6.42
CHEMBL125044 — EC50 = 384.0 nM 6.42