Assay Detail
Functional
CHEMBL1614417
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists. (Class of assay: confirmatory) [Related pubchem assays: 2379 (Confirmation (NR2E3 agonists in quadruplicate)), 2759 (Dose response counterscreen (PPARg and NCOR2 interaction agonists in triplicate)), 2758 (Dose response (NR2E3 agonists in quadruplicate)), 2325 (Summary (NR2E3 agonists)), 2300 (Primary screen (NR2E3 agonists in singlicate))]
114
Total Activities
114
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Category | confirmatory |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Photoreceptor-specific nuclear receptor (CHEMBL4374) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 114 | 5.35 | 6.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1602811 | — | — | 1 | 6.78 |
| CHEMBL1565040 | — | — | 1 | 6.32 |
| CHEMBL312032 | — | — | 1 | 6.13 |
| CHEMBL1482670 | — | — | 1 | 6.11 |
| CHEMBL1417231 | — | — | 1 | 6.09 |
| CHEMBL1392806 | — | — | 1 | 6.07 |
| CHEMBL1601194 | — | — | 1 | 5.98 |
| CHEMBL1405306 | — | — | 1 | 5.93 |
| CHEMBL1358081 | — | — | 1 | 5.85 |
| CHEMBL1302552 | — | — | 1 | 5.84 |
| CHEMBL1368667 | — | — | 1 | 5.79 |
| CHEMBL1407986 | — | — | 1 | 5.70 |
| CHEMBL1304585 | — | — | 1 | 5.68 |
| CHEMBL1562444 | — | — | 1 | 5.64 |
| CHEMBL1410870 | — | — | 1 | 5.63 |
| CHEMBL1519514 | — | — | 1 | 5.63 |
| CHEMBL1482795 | — | — | 1 | 5.61 |
| CHEMBL1488651 | — | — | 1 | 5.60 |
| CHEMBL1607639 | — | — | 1 | 5.58 |
| CHEMBL1391254 | — | — | 1 | 5.58 |
| CHEMBL1485768 | — | — | 1 | 5.57 |
| CHEMBL1464502 | — | — | 1 | 5.54 |
| CHEMBL1464805 | — | — | 1 | 5.54 |
| CHEMBL1375116 | — | — | 1 | 5.52 |
| CHEMBL1401891 | — | — | 1 | 5.50 |
| CHEMBL1539438 | — | — | 1 | 5.47 |
| CHEMBL1523808 | — | — | 1 | 5.47 |
| CHEMBL1471296 | — | — | 1 | 5.47 |
| CHEMBL1369869 | — | — | 1 | 5.46 |
| CHEMBL1442635 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1602811 | — | IC50 | = | 167.27 | nM | 6.78 |
| CHEMBL1565040 | — | IC50 | = | 473.9 | nM | 6.32 |
| CHEMBL312032 | — | IC50 | = | 748.25 | nM | 6.13 |
| CHEMBL1482670 | — | IC50 | = | 774.16 | nM | 6.11 |
| CHEMBL1417231 | — | IC50 | = | 812.55 | nM | 6.09 |
| CHEMBL1392806 | — | IC50 | = | 861.97 | nM | 6.07 |
| CHEMBL1601194 | — | IC50 | = | 1055.0 | nM | 5.98 |
| CHEMBL1405306 | — | IC50 | = | 1173.0 | nM | 5.93 |
| CHEMBL1358081 | — | IC50 | = | 1426.0 | nM | 5.85 |
| CHEMBL1302552 | — | IC50 | = | 1457.0 | nM | 5.84 |
| CHEMBL1368667 | — | IC50 | = | 1613.0 | nM | 5.79 |
| CHEMBL1407986 | — | IC50 | = | 2011.0 | nM | 5.70 |
| CHEMBL1304585 | — | IC50 | = | 2093.0 | nM | 5.68 |
| CHEMBL1562444 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL1410870 | — | IC50 | = | 2331.0 | nM | 5.63 |
| CHEMBL1519514 | — | IC50 | = | 2351.0 | nM | 5.63 |
| CHEMBL1482795 | — | IC50 | = | 2438.0 | nM | 5.61 |
| CHEMBL1488651 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL1607639 | — | IC50 | = | 2605.0 | nM | 5.58 |
| CHEMBL1391254 | — | IC50 | = | 2636.0 | nM | 5.58 |
| CHEMBL1485768 | — | IC50 | = | 2695.0 | nM | 5.57 |
| CHEMBL1464805 | — | IC50 | = | 2861.0 | nM | 5.54 |
| CHEMBL1464502 | — | IC50 | = | 2875.0 | nM | 5.54 |
| CHEMBL1375116 | — | IC50 | = | 2992.0 | nM | 5.52 |
| CHEMBL1401891 | — | IC50 | = | 3136.0 | nM | 5.50 |
| CHEMBL1471296 | — | IC50 | = | 3372.0 | nM | 5.47 |
| CHEMBL1539438 | — | IC50 | = | 3406.0 | nM | 5.47 |
| CHEMBL1523808 | — | IC50 | = | 3383.0 | nM | 5.47 |
| CHEMBL1369869 | — | IC50 | = | 3448.0 | nM | 5.46 |
| CHEMBL1442635 | — | IC50 | = | 3496.0 | nM | 5.46 |
| CHEMBL1358911 | — | IC50 | = | 3533.0 | nM | 5.45 |
| CHEMBL1505334 | — | IC50 | = | 3619.0 | nM | 5.44 |
| CHEMBL1354460 | — | IC50 | = | 3667.0 | nM | 5.44 |
| CHEMBL1544051 | — | IC50 | = | 3677.0 | nM | 5.43 |
| CHEMBL1584932 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL1462884 | — | IC50 | = | 3868.0 | nM | 5.41 |
| CHEMBL1344739 | — | IC50 | = | 3907.0 | nM | 5.41 |
| CHEMBL1304667 | — | IC50 | = | 3968.0 | nM | 5.40 |
| CHEMBL1453623 | — | IC50 | = | 3946.0 | nM | 5.40 |
| CHEMBL1542847 | — | IC50 | = | 4062.0 | nM | 5.39 |
| CHEMBL1531523 | — | IC50 | = | 4294.0 | nM | 5.37 |
| CHEMBL1539768 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL1575283 | — | IC50 | = | 4490.0 | nM | 5.35 |
| CHEMBL1341089 | — | IC50 | = | 4423.0 | nM | 5.35 |
| CHEMBL1513785 | — | IC50 | = | 4460.0 | nM | 5.35 |
| CHEMBL1580310 | — | IC50 | = | 4733.0 | nM | 5.33 |
| CHEMBL1462838 | — | IC50 | = | 4745.0 | nM | 5.32 |
| CHEMBL1601538 | — | IC50 | = | 4849.0 | nM | 5.31 |
| CHEMBL1476478 | — | IC50 | = | 4896.0 | nM | 5.31 |
| CHEMBL1364102 | — | IC50 | = | 4996.0 | nM | 5.30 |