Assay Detail
Functional
CHEMBL1633591
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Antiviral activity against Vaccinia virus WR infected in HFF assessed as reduction of plaque formation after 3 days
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Vaccinia virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.28 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1631219 | — | — | 1 | 7.40 |
| CHEMBL1257073 | TECOVIRIMAT | 4.0 | 1 | 7.16 |
| CHEMBL788 | IDOXURIDINE | 4.0 | 1 | 5.55 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 5.00 |
| CHEMBL1631222 | — | — | 1 | - |
| CHEMBL1631221 | THIARABINE | 1.0 | 1 | - |
| CHEMBL1631220 | — | — | 1 | - |
| CHEMBL1631218 | — | — | 1 | - |
| CHEMBL1629730 | — | — | 1 | - |
| CHEMBL445596 | 4'-THIOTHYMIDINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1631219 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1257073 | TECOVIRIMAT | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL788 | IDOXURIDINE | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1631222 | — | EC50 | - | — | - | |
| CHEMBL1631221 | THIARABINE | EC50 | - | — | - | |
| CHEMBL1631220 | — | EC50 | - | — | - | |
| CHEMBL1631218 | — | EC50 | - | — | - | |
| CHEMBL1629730 | — | EC50 | - | — | - | |
| CHEMBL445596 | 4'-THIOTHYMIDINE | EC50 | - | — | - |