Assay Detail
Binding
CHEMBL1634347
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H[SYM2081 from rat recombinant GluK1(Q)1b expressed in sS9 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | sS9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, kainate 1 (CHEMBL2919) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.41 | 5.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276815 | (S)-AMPA | — | 1 | 5.94 |
| CHEMBL30285 | IBOTENIC ACID | — | 1 | 5.61 |
| CHEMBL154535 | — | — | 1 | 5.35 |
| CHEMBL72366 | — | — | 1 | 5.17 |
| CHEMBL2092841 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276815 | (S)-AMPA | Ki | = | 1150.0 | nM | 5.94 |
| CHEMBL30285 | IBOTENIC ACID | Ki | = | 2430.0 | nM | 5.61 |
| CHEMBL154535 | — | Ki | = | 4480.0 | nM | 5.35 |
| CHEMBL72366 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL2092841 | — | Ki | = | 10100.0 | nM | 5.00 |