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Assay Detail

CHEMBL1638641

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Functional
Cytotoxicity against human Caov3 cells after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Caov-3
Confidence 1 — Organism
Curated By Autocuration

Publication

Structure-cytotoxicity relationship in a series of N-phosphorus substituted E,E-3,5-bis(3-pyridinylmethylene)- and E,E-3,5-bis(4-pyridinylmethylene)piperid-4-ones.
Leonova ES, Makarov MV, Rybalkina EY, Nayani SL, Tongwa P, Fonari A, Timofeeva TV, Odinets IL.
Eur J Med Chem (2010) 45 : 5926 -5934
PubMed 21035234 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.07 5.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1629986 1 5.37
CHEMBL100326 1 5.29
CHEMBL1629985 1 5.22
CHEMBL1629984 1 5.21
CHEMBL1629987 1 5.16
CHEMBL1629980 1 5.09
CHEMBL1629979 1 5.04
CHEMBL1629982 1 5.03
CHEMBL1629981 1 4.97
CHEMBL852 MELPHALAN 4.0 1 4.30
CHEMBL1224771 1 -
CHEMBL1629983 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1629986 IC50 = 4300.0 nM 5.37
CHEMBL100326 IC50 = 5100.0 nM 5.29
CHEMBL1629985 IC50 = 6000.0 nM 5.22
CHEMBL1629984 IC50 = 6200.0 nM 5.21
CHEMBL1629987 IC50 = 7000.0 nM 5.16
CHEMBL1629980 IC50 = 8100.0 nM 5.09
CHEMBL1629979 IC50 = 9200.0 nM 5.04
CHEMBL1629982 IC50 = 9300.0 nM 5.03
CHEMBL1629981 IC50 = 10800.0 nM 4.97
CHEMBL852 MELPHALAN IC50 = 50000.0 nM 4.30
CHEMBL1224771 IC50 > 20000.0 nM -
CHEMBL1629983 IC50 > 40000.0 nM -