Assay Detail
Binding
CHEMBL1638845
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Nalpha-methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Histamine H4 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 7.11 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18661 | IMMEPIP | — | 1 | 9.30 |
| CHEMBL19010 | IODOPROXYFAN | — | 1 | 9.20 |
| CHEMBL82298 | IMMETHRIDINE | — | 1 | 9.10 |
| CHEMBL175782 | METHIMEPIP | — | 1 | 9.00 |
| CHEMBL19439 | IMETIT | — | 1 | 8.80 |
| CHEMBL1632409 | CLOBENPROBIT | — | 1 | 8.60 |
| CHEMBL281576 | — | — | 1 | 8.50 |
| CHEMBL268490 | — | — | 1 | 8.40 |
| CHEMBL90019 | IMBUTAMINE | — | 1 | 8.40 |
| CHEMBL417096 | IMPENTAMINE | — | 1 | 8.30 |
| CHEMBL268229 | — | — | 1 | 8.20 |
| CHEMBL90 | HISTAMINE | 4.0 | 1 | 8.00 |
| CHEMBL19173 | PROXYFAN | — | 1 | 7.90 |
| CHEMBL91353 | HOMOHISTAMINE | — | 1 | 7.30 |
| CHEMBL11919 | — | — | 1 | 7.20 |
| CHEMBL106931 | — | — | 1 | 6.70 |
| CHEMBL106612 | IMIFURAMINE | — | 1 | 6.60 |
| CHEMBL105803 | — | — | 1 | 6.60 |
| CHEMBL320331 | — | — | 1 | 6.50 |
| CHEMBL1196470 | — | — | 1 | 6.00 |
| CHEMBL106913 | — | — | 1 | 5.80 |
| CHEMBL321920 | — | — | 1 | 5.70 |
| CHEMBL321860 | — | — | 1 | 5.70 |
| CHEMBL106158 | — | — | 1 | 5.20 |
| CHEMBL1632410 | — | — | 1 | 5.20 |
| CHEMBL275443 | 4-METHYLHISTAMINE | — | 1 | 5.20 |
| CHEMBL108649 | — | — | 1 | 5.10 |
| CHEMBL322256 | — | — | 1 | 5.00 |
| CHEMBL106570 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18661 | IMMEPIP | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL19010 | IODOPROXYFAN | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL82298 | IMMETHRIDINE | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL175782 | METHIMEPIP | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL19439 | IMETIT | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL1632409 | CLOBENPROBIT | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL281576 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL268490 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL90019 | IMBUTAMINE | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL417096 | IMPENTAMINE | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL268229 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL90 | HISTAMINE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL19173 | PROXYFAN | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL91353 | HOMOHISTAMINE | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL11919 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL106931 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL106612 | IMIFURAMINE | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL105803 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL320331 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL1196470 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL106913 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL321920 | — | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL321860 | — | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL106158 | — | Ki | = | 6309.57 | nM | 5.20 |
| CHEMBL1632410 | — | Ki | = | 6309.57 | nM | 5.20 |
| CHEMBL275443 | 4-METHYLHISTAMINE | Ki | = | 6309.57 | nM | 5.20 |
| CHEMBL108649 | — | Ki | = | 7943.28 | nM | 5.10 |
| CHEMBL322256 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL106570 | — | Ki | = | 19952.62 | nM | 4.70 |