Compound Detail
CHEMBL275443
4-METHYLHISTAMINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL275443 |
| Name | 4-METHYLHISTAMINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UGYXPZQILZRKJJ-UHFFFAOYSA-N |
6
Targets
12
Activities
2
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
125.2
MW (Da)
0.22
ALogP
2
HBA
2
HBD
54.7
PSA (Ų)
0.59
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 9 meas. best 7.5
Ki 3 meas. best 7.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H4 receptor CHEMBL3759 | EC50 | 7.5 | 7.35 | 31.6 | 3 |
| Histamine H4 receptor CHEMBL3759 | Ki | 7.3 | 7.3 | 50.1 | 1 |
| Histamine H4 receptor CHEMBL5657 | EC50 | 5.8 | 5.8 | 1584.9 | 1 |
| Histamine H4 receptor CHEMBL4468 | EC50 | 5.6 | 5.6 | 2511.9 | 1 |
| Histamine H2 receptor CHEMBL1941 | EC50 | 5.54 | 5.52 | 2884.0 | 2 |
| Histamine H3 receptor CHEMBL264 | Ki | 5.2 | 5.2 | 6309.6 | 1 |
| Histamine H2 receptor CHEMBL1941 | Ki | 5.1 | 5.1 | 7943.3 | 1 |
| Histamine H3 receptor CHEMBL264 | EC50 | 4.91 | 4.91 | 12400.0 | 1 |
| Histamine H1 receptor CHEMBL231 | EC50 | 4.8 | 4.8 | 15848.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine