Assay Detail
Functional
CHEMBL1638859
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at histamine H3 receptor in guinea pig ileum
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Histamine H4 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 7.43 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72372 | — | — | 1 | 8.10 |
| CHEMBL72424 | — | — | 1 | 8.00 |
| CHEMBL306077 | — | — | 1 | 7.50 |
| CHEMBL309819 | — | — | 1 | 7.40 |
| CHEMBL72769 | — | — | 1 | 7.30 |
| CHEMBL72431 | — | — | 1 | 7.10 |
| CHEMBL12160 | BURIMAMIDE | — | 1 | 7.00 |
| CHEMBL308913 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72372 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL72424 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL306077 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL309819 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL72769 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL72431 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL12160 | BURIMAMIDE | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL308913 | — | Kd | = | 100.0 | nM | 7.00 |