Compound Detail
CHEMBL306077
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Basic Information
| ChEMBL ID | CHEMBL306077 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BAFIAMAZLRISIH-UHFFFAOYSA-N |
2
Targets
4
Activities
3
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
240.4
MW (Da)
2.02
ALogP
2
HBA
3
HBD
53.1
PSA (Ų)
0.31
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 2 meas. best 7.5
EC50 1 meas. best 7.7
Ki 1 meas. best 8.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H4 receptor CHEMBL3759 | Ki | 8.1 | 8.1 | 7.9 | 1 |
| Histamine H4 receptor CHEMBL3759 | EC50 | 7.7 | 7.7 | 19.9 | 1 |
| Histamine H3 receptor CHEMBL5076 | Kd | 7.5 | 7.5 | 31.6 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H4 receptor | Ki | = | 7.943 | nM | 8.1 | Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9... | 21044842 |
| Histamine H4 receptor | EC50 | = | 19.95 | nM | 7.7 | Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells... | 21044842 |
| Histamine H3 receptor | Kd | = | 31.62 | nM | 7.5 | In vitro inhibitory effect of histamine H3 antagonist on the electrically evoked... | 7783156 |
| Histamine H3 receptor | Kd | = | 31.62 | nM | 7.5 | Agonist activity at histamine H3 receptor in guinea pig ileum | 21044842 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21044842 | 10.1016/j.bmcl.2010.10.041 | Histamine H4 receptor | 3 |
| 7783156 | 10.1021/jm00012a025 | Histamine H3 receptor | 1 |
| 21044842 | 10.1016/j.bmcl.2010.10.041 | Histamine H3 receptor | 1 |
Data from ChEMBL 36 via Core Engine