Assay Detail
Functional
CHEMBL1640296
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 isolate 153 harboring reverse transcriptase L74V mutant gene by phenosense assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Development of hexadecyloxypropyl tenofovir (CMX157) for treatment of infection caused by wild-type and nucleoside/nucleotide-resistant HIV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.35 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL515564 | TENOFOVIR EXALIDEX | 2.0 | 1 | 8.92 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.96 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 6.32 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 6.22 |
| CHEMBL885 | EMTRICITABINE | 4.0 | 1 | 5.68 |
| CHEMBL1380 | ABACAVIR | 4.0 | 1 | 5.47 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 5.16 |
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL515564 | TENOFOVIR EXALIDEX | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL991 | STAVUDINE | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL885 | EMTRICITABINE | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1380 | ABACAVIR | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1460 | DIDANOSINE | EC50 | = | 8900.0 | nM | 5.05 |