Assay Detail
Functional
CHEMBL1641027
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Antiviral activity against HIV1 isolate 188 harboring reverse transcriptase T215Y/M184V mutant gene by phenosense assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Development of hexadecyloxypropyl tenofovir (CMX157) for treatment of infection caused by wild-type and nucleoside/nucleotide-resistant HIV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.42 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL515564 | TENOFOVIR EXALIDEX | 2.0 | 1 | 8.77 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.15 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 6.21 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 6.19 |
| CHEMBL1380 | ABACAVIR | 4.0 | 1 | 5.12 |
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 5.10 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | - |
| CHEMBL885 | EMTRICITABINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL515564 | TENOFOVIR EXALIDEX | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL991 | STAVUDINE | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL1380 | ABACAVIR | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL1460 | DIDANOSINE | EC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL141 | LAMIVUDINE | EC50 | > | 300000.0 | nM | - |
| CHEMBL885 | EMTRICITABINE | EC50 | > | 100000.0 | nM | - |