Assay Detail
Functional
CHEMBL1641038
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Antiviral activity against HIV1 isolate 217 harboring reverse transcriptase D67N/K70E/M184V mutant gene by phenosense assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Development of hexadecyloxypropyl tenofovir (CMX157) for treatment of infection caused by wild-type and nucleoside/nucleotide-resistant HIV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.72 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL515564 | TENOFOVIR EXALIDEX | 2.0 | 1 | 8.82 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.40 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 6.38 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 6.30 |
| CHEMBL1380 | ABACAVIR | 4.0 | 1 | 5.29 |
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 5.14 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | - |
| CHEMBL885 | EMTRICITABINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL515564 | TENOFOVIR EXALIDEX | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL991 | STAVUDINE | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1380 | ABACAVIR | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1460 | DIDANOSINE | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL141 | LAMIVUDINE | EC50 | > | 300000.0 | nM | - |
| CHEMBL885 | EMTRICITABINE | EC50 | > | 100000.0 | nM | - |