Assay Detail
ADMET
CHEMBL1645654
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Inhibition of CYP2C9
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.03 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1643783 | — | — | 1 | 5.38 |
| CHEMBL1643780 | — | — | 1 | 5.19 |
| CHEMBL561132 | MK-7246 | 1.0 | 1 | 5.03 |
| CHEMBL1643773 | — | — | 1 | 4.87 |
| CHEMBL1643789 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1643783 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL1643780 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL561132 | MK-7246 | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL1643773 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL1643789 | — | IC50 | = | 21000.0 | nM | 4.68 |