Assay Detail
Binding
CHEMBL1645745
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Inhibition of [3H]E1 binding to human placental 17beta-HSD1 after 20 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
17-beta-hydroxysteroid dehydrogenase type 1 (CHEMBL3181) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
17β-HSD2 inhibitors for the treatment of osteoporosis: Identification of a promising scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.96 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL195217 | — | — | 1 | 6.94 |
| CHEMBL1644043 | — | — | 1 | 6.21 |
| CHEMBL193726 | — | — | 1 | 5.62 |
| CHEMBL1644047 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL195217 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL1644043 | — | IC50 | = | 614.0 | nM | 6.21 |
| CHEMBL193726 | — | IC50 | = | 2425.0 | nM | 5.62 |
| CHEMBL1644047 | — | IC50 | = | 8516.0 | nM | 5.07 |