Assay Detail
ADMET
CHEMBL1646221
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Inhibition of human CYP3A4
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel serotonin type 3 receptor partial agonists for the potential treatment of irritable bowel syndrome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.63 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1110 | ALOSETRON | 4.0 | 1 | 6.22 |
| CHEMBL1643880 | PUMOSETRAG | 2.0 | 1 | 5.03 |
| CHEMBL1643881 | — | — | 1 | - |
| CHEMBL1643883 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1110 | ALOSETRON | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1643880 | PUMOSETRAG | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL1643881 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL1643883 | — | IC50 | < | 10000.0 | nM | - |