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Assay Detail

CHEMBL1646377

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Functional
Antiplatelet activity against pig platelet assessed as inhibition of ADP-induced platelet aggregation by spectrophotometry
ChEMBL ↗
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Sus scrofa
Cell Type Platelet
Confidence 1 — Organism
Curated By Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗
Type NON-MOLECULAR

Publication

2-Substituted (S)-2-(3,3-dimethyl-1-oxo-10,10a-dihydroimidazo[1,5-b]isoquinolin-2(1H,3H,5H)-yl)acetic acids: Conformational prediction, synthesis, anti-thrombotic and vasodilative evaluation.
Wang H, Peng L, Zhao M, Liu J, Zhang X, Wang Y, Wu J, Li L, Peng S.
Bioorg Med Chem (2011) 19 : 871 -882
PubMed 21193315 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 38 6.59 6.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1643077 — — 1 6.92
CHEMBL576424 — — 1 6.91
CHEMBL1642830 — — 1 6.80
CHEMBL1642819 — — 1 6.80
CHEMBL1642821 — — 1 6.79
CHEMBL566184 — — 1 6.79
CHEMBL1642817 — — 1 6.77
CHEMBL1642818 — — 1 6.76
CHEMBL1641616 — — 1 6.76
CHEMBL1642832 — — 1 6.75
CHEMBL1642829 — — 1 6.74
CHEMBL569924 — — 1 6.73
CHEMBL1642826 — — 1 6.72
CHEMBL567664 — — 1 6.71
CHEMBL1642820 — — 1 6.70
CHEMBL1642823 — — 1 6.70
CHEMBL1642827 — — 1 6.68
CHEMBL566608 — — 1 6.64
CHEMBL576444 — — 1 6.64
CHEMBL576214 — — 1 6.63
CHEMBL1642825 — — 1 6.61
CHEMBL1642831 — — 1 6.58
CHEMBL1642822 — — 1 6.56
CHEMBL1642828 — — 1 6.55
CHEMBL1642824 — — 1 6.53
CHEMBL566792 — — 1 6.48
CHEMBL565296 — — 1 6.46
CHEMBL1643078 — — 1 6.44
CHEMBL565336 — — 1 6.42
CHEMBL569455 — — 1 6.41

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1643077 — IC50 = 120.0 nM 6.92
CHEMBL576424 — IC50 = 124.0 nM 6.91
CHEMBL1642819 — IC50 = 158.5 nM 6.80
CHEMBL1642830 — IC50 = 158.8 nM 6.80
CHEMBL1642821 — IC50 = 163.1 nM 6.79
CHEMBL566184 — IC50 = 164.0 nM 6.79
CHEMBL1642817 — IC50 = 171.0 nM 6.77
CHEMBL1642818 — IC50 = 175.2 nM 6.76
CHEMBL1641616 — IC50 = 172.9 nM 6.76
CHEMBL1642832 — IC50 = 179.7 nM 6.75
CHEMBL1642829 — IC50 = 182.0 nM 6.74
CHEMBL569924 — IC50 = 188.0 nM 6.73
CHEMBL1642826 — IC50 = 190.7 nM 6.72
CHEMBL567664 — IC50 = 194.0 nM 6.71
CHEMBL1642823 — IC50 = 198.0 nM 6.70
CHEMBL1642820 — IC50 = 199.5 nM 6.70
CHEMBL1642827 — IC50 = 207.4 nM 6.68
CHEMBL566608 — IC50 = 229.0 nM 6.64
CHEMBL576444 — IC50 = 231.0 nM 6.64
CHEMBL576214 — IC50 = 235.0 nM 6.63
CHEMBL1642825 — IC50 = 248.3 nM 6.61
CHEMBL1642831 — IC50 = 264.2 nM 6.58
CHEMBL1642822 — IC50 = 272.9 nM 6.56
CHEMBL1642828 — IC50 = 283.3 nM 6.55
CHEMBL1642824 — IC50 = 293.9 nM 6.53
CHEMBL566792 — IC50 = 329.0 nM 6.48
CHEMBL565296 — IC50 = 350.0 nM 6.46
CHEMBL1643078 — IC50 = 364.0 nM 6.44
CHEMBL565336 — IC50 = 382.0 nM 6.42
CHEMBL569455 — IC50 = 388.0 nM 6.41
CHEMBL565295 — IC50 = 470.0 nM 6.33
CHEMBL576870 — IC50 = 478.0 nM 6.32
CHEMBL593762 — IC50 = 481.0 nM 6.32
CHEMBL566592 — IC50 = 482.0 nM 6.32
CHEMBL565335 — IC50 = 496.0 nM 6.30
CHEMBL569033 — IC50 = 540.0 nM 6.27
CHEMBL447576 — IC50 = 541.7 nM 6.27
CHEMBL566157 — IC50 = 661.0 nM 6.18