Assay Detail
Functional
CHEMBL1646378
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplatelet activity against pig platelet assessed as inhibition of arachidonic acid-induced platelet aggregation by spectrophotometry
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Sus scrofa |
| Cell Type | Platelet |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-Substituted (S)-2-(3,3-dimethyl-1-oxo-10,10a-dihydroimidazo[1,5-b]isoquinolin-2(1H,3H,5H)-yl)acetic acids: Conformational prediction, synthesis, anti-thrombotic and vasodilative evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 6.50 | 6.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1643078 | — | — | 1 | 6.99 |
| CHEMBL565296 | — | — | 1 | 6.98 |
| CHEMBL565335 | — | — | 1 | 6.97 |
| CHEMBL565295 | — | — | 1 | 6.78 |
| CHEMBL566608 | — | — | 1 | 6.72 |
| CHEMBL1642819 | — | — | 1 | 6.57 |
| CHEMBL1642830 | — | — | 1 | 6.57 |
| CHEMBL567664 | — | — | 1 | 6.56 |
| CHEMBL1642821 | — | — | 1 | 6.56 |
| CHEMBL1641616 | — | — | 1 | 6.54 |
| CHEMBL576870 | — | — | 1 | 6.54 |
| CHEMBL1642817 | — | — | 1 | 6.54 |
| CHEMBL1642818 | — | — | 1 | 6.53 |
| CHEMBL1642832 | — | — | 1 | 6.53 |
| CHEMBL1642829 | — | — | 1 | 6.52 |
| CHEMBL1642826 | — | — | 1 | 6.50 |
| CHEMBL1642820 | — | — | 1 | 6.49 |
| CHEMBL1642823 | — | — | 1 | 6.49 |
| CHEMBL1642827 | — | — | 1 | 6.47 |
| CHEMBL566592 | — | — | 1 | 6.45 |
| CHEMBL576424 | — | — | 1 | 6.44 |
| CHEMBL1643077 | — | — | 1 | 6.43 |
| CHEMBL565336 | — | — | 1 | 6.41 |
| CHEMBL566792 | — | — | 1 | 6.41 |
| CHEMBL593762 | — | — | 1 | 6.41 |
| CHEMBL1642825 | — | — | 1 | 6.41 |
| CHEMBL1642831 | — | — | 1 | 6.39 |
| CHEMBL569455 | — | — | 1 | 6.38 |
| CHEMBL1642822 | — | — | 1 | 6.38 |
| CHEMBL566184 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1643078 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL565296 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL565335 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL565295 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL566608 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL1642819 | — | IC50 | = | 271.1 | nM | 6.57 |
| CHEMBL1642830 | — | IC50 | = | 271.1 | nM | 6.57 |
| CHEMBL567664 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL1642821 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL1642817 | — | IC50 | = | 287.3 | nM | 6.54 |
| CHEMBL576870 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1641616 | — | IC50 | = | 289.8 | nM | 6.54 |
| CHEMBL1642818 | — | IC50 | = | 292.4 | nM | 6.53 |
| CHEMBL1642832 | — | IC50 | = | 298.6 | nM | 6.53 |
| CHEMBL1642829 | — | IC50 | = | 301.6 | nM | 6.52 |
| CHEMBL1642826 | — | IC50 | = | 312.9 | nM | 6.50 |
| CHEMBL1642820 | — | IC50 | = | 324.3 | nM | 6.49 |
| CHEMBL1642823 | — | IC50 | = | 322.4 | nM | 6.49 |
| CHEMBL1642827 | — | IC50 | = | 334.6 | nM | 6.47 |
| CHEMBL566592 | — | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL576424 | — | IC50 | = | 361.0 | nM | 6.44 |
| CHEMBL1643077 | — | IC50 | = | 374.0 | nM | 6.43 |
| CHEMBL565336 | — | IC50 | = | 388.0 | nM | 6.41 |
| CHEMBL566792 | — | IC50 | = | 391.0 | nM | 6.41 |
| CHEMBL593762 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1642825 | — | IC50 | = | 387.8 | nM | 6.41 |
| CHEMBL1642831 | — | IC50 | = | 408.5 | nM | 6.39 |
| CHEMBL566184 | — | IC50 | = | 418.0 | nM | 6.38 |
| CHEMBL1642822 | — | IC50 | = | 419.7 | nM | 6.38 |
| CHEMBL569455 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL1642828 | — | IC50 | = | 433.3 | nM | 6.36 |
| CHEMBL1642824 | — | IC50 | = | 447.1 | nM | 6.35 |
| CHEMBL569033 | — | IC50 | = | 443.0 | nM | 6.35 |
| CHEMBL576444 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL447576 | — | IC50 | = | 481.4 | nM | 6.32 |
| CHEMBL576214 | — | IC50 | = | 494.0 | nM | 6.31 |
| CHEMBL566157 | — | IC50 | = | 491.0 | nM | 6.31 |
| CHEMBL569924 | — | IC50 | = | 553.0 | nM | 6.26 |