Assay Detail
Binding
CHEMBL1646403
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of (+)-[3H]pentazocine from sigma 1 receptor in rat PC12 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | PC-12 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL3602) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.54 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1643900 | — | — | 1 | 7.72 |
| CHEMBL1643899 | — | — | 1 | 6.70 |
| CHEMBL1643902 | — | — | 1 | 5.93 |
| CHEMBL1643901 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1643900 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL1643899 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL1643902 | — | Ki | = | 1163.0 | nM | 5.93 |
| CHEMBL1643901 | — | Ki | = | 1571.0 | nM | 5.80 |