Assay Detail
Binding
CHEMBL1646713
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Inhibition of human steroid-11beta-hydroxylase expressed in chinese hamster V79 cells using 11-deoxycorticosterone as substrate
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.28 | 7.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL934 | METYRAPONE | 4.0 | 1 | 7.84 |
| CHEMBL1645416 | — | — | 1 | 5.23 |
| CHEMBL1645412 | — | — | 1 | 5.12 |
| CHEMBL1645408 | — | — | 1 | 4.99 |
| CHEMBL1645407 | — | — | 1 | 4.84 |
| CHEMBL1645418 | — | — | 1 | 4.79 |
| CHEMBL1645409 | — | — | 1 | 4.78 |
| CHEMBL1645413 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL934 | METYRAPONE | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL1645416 | — | IC50 | = | 5920.0 | nM | 5.23 |
| CHEMBL1645412 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL1645408 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL1645407 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL1645418 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL1645409 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL1645413 | — | IC50 | = | 24800.0 | nM | 4.61 |