Assay Detail
Binding
CHEMBL1647124
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation counting
32
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.42 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1642904 | — | — | 1 | 9.00 |
| CHEMBL1642912 | — | — | 1 | 9.00 |
| CHEMBL1642902 | — | — | 1 | 8.70 |
| CHEMBL809 | SERTRALINE | 4.0 | 1 | 8.52 |
| CHEMBL1642900 | — | — | 1 | 8.52 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 8.28 |
| CHEMBL1642894 | — | — | 1 | 8.22 |
| CHEMBL1642898 | — | — | 1 | 8.15 |
| CHEMBL1642896 | — | — | 1 | 8.10 |
| CHEMBL1642906 | — | — | 1 | 8.05 |
| CHEMBL592374 | AMITIFADINE | 2.0 | 2 | 7.92 |
| CHEMBL1642909 | — | — | 1 | 7.80 |
| CHEMBL1642903 | — | — | 1 | 7.72 |
| CHEMBL1642901 | — | — | 1 | 7.70 |
| CHEMBL1642908 | — | — | 1 | 7.64 |
| CHEMBL1642914 | — | — | 1 | 7.38 |
| CHEMBL1642890 | — | — | 1 | 7.34 |
| CHEMBL1642907 | — | — | 1 | 7.27 |
| CHEMBL1642905 | — | — | 1 | 7.21 |
| CHEMBL1642913 | — | — | 1 | 7.10 |
| CHEMBL1642892 | — | — | 1 | 7.08 |
| CHEMBL1642893 | — | — | 1 | 6.97 |
| CHEMBL1642899 | — | — | 1 | 6.97 |
| CHEMBL1642897 | — | — | 1 | 6.97 |
| CHEMBL1642895 | — | — | 1 | 6.90 |
| CHEMBL1642910 | — | — | 1 | 6.51 |
| CHEMBL1642911 | — | — | 1 | 6.01 |
| CHEMBL1642891 | — | — | 1 | 5.74 |
| CHEMBL1642915 | — | — | 1 | 5.71 |
| CHEMBL1642916 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1642912 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1642904 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1642902 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL809 | SERTRALINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1642900 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL41 | FLUOXETINE | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL1642894 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1642898 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1642896 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1642906 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL592374 | AMITIFADINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL592374 | AMITIFADINE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1642909 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1642903 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1642901 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1642908 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1642914 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1642890 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1642907 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1642905 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1642913 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL1642892 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL1642899 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL1642897 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL1642893 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL1642895 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL1642910 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL1642911 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL1642891 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL1642915 | — | IC50 | = | 1956.0 | nM | 5.71 |
| CHEMBL1642916 | — | IC50 | = | 2495.0 | nM | 5.60 |
| CHEMBL1642917 | — | IC50 | = | 2827.0 | nM | 5.55 |