Assay Detail
Functional
CHEMBL1647394
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Antiproliferative activity against human A2780 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel pyrrolo[2,1-f][1,2,4]triazin-4-amines: Dual inhibitors of EGFR and HER2 protein tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.49 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1645466 | — | — | 1 | 5.64 |
| CHEMBL1645474 | — | — | 1 | 5.58 |
| CHEMBL1645467 | — | — | 1 | 5.43 |
| CHEMBL1645465 | — | — | 1 | 5.41 |
| CHEMBL1645475 | — | — | 1 | 5.40 |
| CHEMBL1645469 | — | — | 1 | - |
| CHEMBL1645470 | — | — | 1 | - |
| CHEMBL1645471 | — | — | 1 | - |
| CHEMBL1645472 | — | — | 1 | - |
| CHEMBL1645473 | — | — | 1 | - |
| CHEMBL1645476 | — | — | 1 | - |
| CHEMBL1645477 | — | — | 1 | - |
| CHEMBL1645463 | — | — | 1 | - |
| CHEMBL1645464 | — | — | 1 | - |
| CHEMBL1645468 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1645466 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1645474 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1645467 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1645465 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1645475 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1645469 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1645470 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1645471 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1645472 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1645473 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1645476 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1645477 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1645463 | — | IC50 | - | — | - | |
| CHEMBL1645464 | — | IC50 | - | — | - | |
| CHEMBL1645468 | — | IC50 | - | — | - |