Assay Detail
Binding
CHEMBL1647666
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Inhibition of ROCK-1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.33 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL559147 | Y-27632 | — | 1 | 7.60 |
| CHEMBL1233300 | HYDROXYFASUDIL | — | 1 | 7.50 |
| CHEMBL1643361 | — | — | 1 | 7.20 |
| CHEMBL38380 | FASUDIL | 3.0 | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL559147 | Y-27632 | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL1233300 | HYDROXYFASUDIL | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1643361 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL38380 | FASUDIL | Ki | = | 100.0 | nM | 7.00 |