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Assay Detail

CHEMBL1648843

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation.
Reid CS, Patrick DA, He S, Fotie J, Premalatha K, Tidwell RR, Wang MZ, Liu Q, Gershkovich P, Wasan KM, Wenzler T, Brun R, Werbovetz KA.
Bioorg Med Chem (2011) 19 : 513 -523
PubMed 21112788 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 4.89 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL61 PODOFILOX 4.0 1 7.92
CHEMBL35241 DIMINAZENE 2.0 1 5.30
CHEMBL1644657 1 5.00
CHEMBL1644658 1 4.96
CHEMBL1644659 1 4.96
CHEMBL1644660 1 4.92
CHEMBL1644655 1 4.77
CHEMBL1644656 1 4.77
CHEMBL566743 1 4.75
CHEMBL1644664 1 4.66
CHEMBL55 PENTAMIDINE 4.0 1 4.60
CHEMBL1644662 1 4.32
CHEMBL1644667 1 4.31
CHEMBL1644654 1 4.05
CHEMBL1644653 1 4.01
CHEMBL1644663 1 -
CHEMBL1644665 1 -
CHEMBL1644666 1 -
CHEMBL166 MELARSOPROL 3.0 1 -
CHEMBL1644661 1 -
CHEMBL265502 SURAMIN 3.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL61 PODOFILOX IC50 = 12.0 nM 7.92
CHEMBL35241 DIMINAZENE IC50 = 5000.0 nM 5.30
CHEMBL1644657 IC50 = 10000.0 nM 5.00
CHEMBL1644658 IC50 = 11000.0 nM 4.96
CHEMBL1644659 IC50 = 11000.0 nM 4.96
CHEMBL1644660 IC50 = 12000.0 nM 4.92
CHEMBL1644655 IC50 = 17000.0 nM 4.77
CHEMBL1644656 IC50 = 17000.0 nM 4.77
CHEMBL566743 IC50 = 18000.0 nM 4.75
CHEMBL1644664 IC50 = 22000.0 nM 4.66
CHEMBL55 PENTAMIDINE IC50 = 25000.0 nM 4.60
CHEMBL1644662 IC50 = 48000.0 nM 4.32
CHEMBL1644667 IC50 = 49000.0 nM 4.31
CHEMBL1644654 IC50 = 90000.0 nM 4.05
CHEMBL1644653 IC50 = 97000.0 nM 4.01
CHEMBL1644663 IC50 - -
CHEMBL1644665 IC50 > 190000.0 nM -
CHEMBL1644666 IC50 - -
CHEMBL166 MELARSOPROL IC50 - -
CHEMBL1644661 IC50 = 110000.0 nM -
CHEMBL265502 SURAMIN IC50 - -