Assay Detail
Binding
CHEMBL1648866
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Binding affinity to progesterone receptor
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Tetrahydroquinoline glucocorticoid receptor agonists: discovery of a 3-hydroxyl for improving receptor selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.46 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258191 | — | — | 1 | 7.89 |
| CHEMBL1644755 | — | — | 1 | 7.85 |
| CHEMBL1644756 | — | — | 1 | 7.60 |
| CHEMBL1644754 | — | — | 1 | 7.16 |
| CHEMBL1644758 | — | — | 1 | 6.57 |
| CHEMBL1644757 | — | — | 1 | 6.38 |
| CHEMBL1644765 | — | — | 1 | 5.96 |
| CHEMBL1644759 | — | — | 1 | 5.92 |
| CHEMBL1644761 | — | — | 1 | 5.89 |
| CHEMBL1644760 | — | — | 2 | 5.85 |
| CHEMBL1644764 | — | — | 1 | 5.72 |
| CHEMBL1644763 | — | — | 1 | 5.52 |
| CHEMBL1644762 | — | — | 1 | - |
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258191 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL1644755 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL1644756 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL1644754 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL1644758 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL1644757 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL1644765 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL1644759 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL1644761 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL1644760 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL1644764 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL1644760 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL1644763 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL1644762 | — | Ki | - | — | - | |
| CHEMBL131 | PREDNISOLONE | Ki | - | — | - |