Compound Detail
CHEMBL1644756
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Basic Information
| ChEMBL ID | CHEMBL1644756 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HUPZROPFBRSFDW-UHFFFAOYSA-N |
2
Targets
5
Activities
3
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
392.9
MW (Da)
6.40
ALogP
2
HBA
2
HBD
44.9
PSA (Ų)
0.51
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.68
Ki 2 meas. best 8.46
EC50 1 meas. best 8.13
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucocorticoid receptor CHEMBL2034 | IC50 | 8.68 | 8.06 | 2.1 | 2 |
| Glucocorticoid receptor CHEMBL2034 | Ki | 8.46 | 8.46 | 3.5 | 1 |
| Glucocorticoid receptor CHEMBL2034 | EC50 | 8.13 | 8.13 | 7.4 | 1 |
| Progesterone receptor CHEMBL208 | Ki | 7.6 | 7.6 | 25.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | IC50 | = | 2.1 | nM | 8.68 | Transrepression activity at glucocorticoid receptor in TNFalpha/IL1beta-stimulat... | 21115247 |
| Glucocorticoid receptor | Ki | = | 3.5 | nM | 8.46 | Displacement of radiolabeled Dexamethasone from glucocorticoid receptor expresse... | 21115247 |
| Glucocorticoid receptor | EC50 | = | 7.4 | nM | 8.13 | Agonist activity at glucocorticoid receptor in human HepG2 cells co-transfected ... | 21115247 |
| Progesterone receptor | Ki | = | 25.0 | nM | 7.6 | Binding affinity to progesterone receptor | 21115247 |
| Glucocorticoid receptor | IC50 | = | 36.0 | nM | 7.44 | Transrepression activity at glucocorticoid receptor in IL-1beta-stimulated human... | 21115247 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21115247 | 10.1016/j.bmcl.2010.11.047 | Glucocorticoid receptor | 7 |
| 21115247 | 10.1016/j.bmcl.2010.11.047 | Progesterone receptor | 1 |
Data from ChEMBL 36 via Core Engine