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Assay Detail

CHEMBL1656141

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HL60R cells after 72 hrs by MTS assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Autocuration

Publication

Novel flavaglines displaying improved cytotoxicity.
Thuaud F, Ribeiro N, Gaiddon C, Cresteil T, Désaubry L.
J Med Chem (2011) 54 : 411 -415
PubMed 21142180 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 7.56 8.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1651463 1 8.82
CHEMBL1651465 1 8.77
CHEMBL1651466 1 8.43
CHEMBL556074 1 8.35
CHEMBL1651425 1 8.29
CHEMBL1651416 1 7.92
CHEMBL1651415 1 7.85
CHEMBL1651417 1 7.80
CHEMBL1651418 1 7.75
CHEMBL1651467 1 7.66
CHEMBL1651421 1 7.55
CHEMBL1651420 1 7.36
CHEMBL1651419 1 7.17
CHEMBL1651422 1 7.11
CHEMBL1651464 1 7.09
CHEMBL1651423 1 6.92
CHEMBL1651429 1 6.44
CHEMBL3545252 DOCETAXEL 4.0 1 6.28
CHEMBL53463 DOXORUBICIN 4.0 1 6.00
CHEMBL159 VINBLASTINE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1651463 IC50 = 1.5 nM 8.82
CHEMBL1651465 IC50 = 1.7 nM 8.77
CHEMBL1651466 IC50 = 3.7 nM 8.43
CHEMBL556074 IC50 = 4.5 nM 8.35
CHEMBL1651425 IC50 = 5.1 nM 8.29
CHEMBL1651416 IC50 = 12.0 nM 7.92
CHEMBL1651415 IC50 = 14.0 nM 7.85
CHEMBL1651417 IC50 = 16.0 nM 7.80
CHEMBL1651418 IC50 = 18.0 nM 7.75
CHEMBL1651467 IC50 = 22.0 nM 7.66
CHEMBL1651421 IC50 = 28.0 nM 7.55
CHEMBL1651420 IC50 = 44.0 nM 7.36
CHEMBL1651419 IC50 = 67.0 nM 7.17
CHEMBL1651422 IC50 = 78.0 nM 7.11
CHEMBL1651464 IC50 = 82.0 nM 7.09
CHEMBL1651423 IC50 = 121.0 nM 6.92
CHEMBL1651429 IC50 = 361.0 nM 6.44
CHEMBL3545252 DOCETAXEL IC50 = 531.0 nM 6.28
CHEMBL53463 DOXORUBICIN IC50 = 990.0 nM 6.00
CHEMBL159 VINBLASTINE IC50 > 100.0 nM -