Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL1651423

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3ccc(OC)cc3O[C@@]2(c2ccc(OC)cc2)[C@@H]1c1ccccc1

Basic Information

ChEMBL ID CHEMBL1651423
Phase Preclinical
Structure Type MOL
InChI Key YDGUGHBBJDUJJF-MMDQJTGWSA-N
6
Targets
8
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

462.5
MW (Da)
3.13
ALogP
7
HBA
2
HBD
94.5
PSA (Ų)
0.56
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H26O7
MW 462.50
Aromatic Rings 3
Heavy Atoms 34
NP-Likeness 1.20

Activity Summary

IC50 8 meas. best 7.29

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NON-PROTEIN TARGET
CHEMBL3879801
IC50 7.29 6.9133 51.0 3
HL-60
CHEMBL383
IC50 6.71 6.71 195.0 1
HCT-116
CHEMBL394
IC50 6.7 6.7 202.0 1
SK-OV-3
CHEMBL614925
IC50 6.58 6.58 260.0 1
PC-3
CHEMBL390
IC50 6.56 6.56 273.0 1
KB
CHEMBL398
IC50 6.47 6.47 340.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21142180 10.1021/jm101318b NON-PROTEIN TARGET 3
21142180 10.1021/jm101318b HL-60 1
21142180 10.1021/jm101318b KB 1
21142180 10.1021/jm101318b HCT-116 1
21142180 10.1021/jm101318b SK-OV-3 1
21142180 10.1021/jm101318b PC-3 1

Data from ChEMBL 36 via Core Engine