Assay Detail
Binding
CHEMBL1656352
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Inhibition of human CYP11B1 expressed in hamster V79MZ cells using 11-deoxycorticosterone substrate
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79MZ |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 7.26 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL681 | ETOMIDATE | 4.0 | 1 | 9.30 |
| CHEMBL1651507 | — | — | 1 | 8.52 |
| CHEMBL1651508 | — | — | 1 | 8.40 |
| CHEMBL1651495 | — | — | 1 | 8.30 |
| CHEMBL1651505 | — | — | 1 | 8.30 |
| CHEMBL1651496 | — | — | 1 | 7.82 |
| CHEMBL934 | METYRAPONE | 4.0 | 1 | 7.82 |
| CHEMBL403598 | — | — | 1 | 7.72 |
| CHEMBL1649605 | — | — | 1 | 7.62 |
| CHEMBL1651494 | — | — | 1 | 7.50 |
| CHEMBL1235146 | — | — | 1 | 7.50 |
| CHEMBL1651514 | — | — | 1 | 7.37 |
| CHEMBL1651497 | — | — | 1 | 7.34 |
| CHEMBL1651513 | — | — | 1 | 7.34 |
| CHEMBL1651493 | — | — | 1 | 7.32 |
| CHEMBL1651492 | — | — | 1 | 7.21 |
| CHEMBL1651506 | — | — | 1 | 7.12 |
| CHEMBL1651509 | — | — | 1 | 7.10 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 6.90 |
| CHEMBL1651498 | — | — | 1 | 6.89 |
| CHEMBL14192 | BENZYLIMIDAZOLE | — | 1 | 6.87 |
| CHEMBL441367 | — | — | 1 | 6.85 |
| CHEMBL428780 | — | — | 1 | 6.82 |
| CHEMBL1651499 | — | — | 1 | 6.73 |
| CHEMBL1450329 | — | — | 1 | 6.71 |
| CHEMBL1651503 | — | — | 1 | 6.71 |
| CHEMBL347547 | — | — | 1 | 6.61 |
| CHEMBL212741 | — | — | 1 | 6.59 |
| CHEMBL1651502 | — | — | 1 | 6.43 |
| CHEMBL1428763 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL681 | ETOMIDATE | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1651507 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1651508 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1651495 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1651505 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1651496 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL934 | METYRAPONE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL403598 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1649605 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1651494 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1235146 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1651514 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1651497 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1651513 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1651493 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL1651492 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1651506 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL1651509 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL1651498 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL14192 | BENZYLIMIDAZOLE | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL441367 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL428780 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL1651499 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL1450329 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL1651503 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL347547 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL212741 | — | IC50 | = | 258.0 | nM | 6.59 |
| CHEMBL1651502 | — | IC50 | = | 369.0 | nM | 6.43 |
| CHEMBL1428763 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1444873 | — | IC50 | = | 635.0 | nM | 6.20 |
| CHEMBL1328035 | — | IC50 | = | 779.0 | nM | 6.11 |
| CHEMBL1507088 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1651500 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1651501 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1651504 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1651510 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1651511 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1651512 | — | IC50 | > | 1000.0 | nM | - |