Assay Detail
Functional
CHEMBL1657162
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Antiviral activity against VZV OKA expressing thymidine kinase infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 5 days
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.98 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 7.92 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 7.36 |
| CHEMBL1650763 | — | — | 1 | 6.39 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.48 |
| CHEMBL1650765 | — | — | 1 | 4.70 |
| CHEMBL1650766 | — | — | 1 | 4.01 |
| CHEMBL1650764 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1650763 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1650765 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1650766 | — | EC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL1650764 | — | EC50 | > | 40000.0 | nM | - |