Assay Detail
Functional
CHEMBL1657308
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Inhibition of antiTCR/antiCD28-stimulated IL2 production in human Jurkat cells by measuring bioluminescence
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.16 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1650951 | — | — | 1 | 6.16 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1650951 | — | IC50 | = | 689.0 | nM | 6.16 |
| CHEMBL221959 | TOFACITINIB | IC50 | > | 5000.0 | nM | - |