Assay Detail
Functional
CHEMBL1659130
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Antitrypanosomal activity against Trypanosoma brucei BSF overexpressing NTR gene assessed as growth inhibition after 3 days by Alamar blue assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Trypanocidal activity of aziridinyl nitrobenzamide prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.78 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL321399 | — | — | 1 | 6.05 |
| CHEMBL1650838 | — | — | 1 | 5.84 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 5.69 |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | 5.53 |
| CHEMBL1650840 | — | — | 1 | - |
| CHEMBL111860 | — | — | 1 | - |
| CHEMBL112126 | — | — | 1 | - |
| CHEMBL1650839 | — | — | 1 | - |
| CHEMBL324103 | — | — | 1 | - |
| CHEMBL112527 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL321399 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL1650838 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL23330 | TRETAZICAR | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL1650840 | — | IC50 | > | 6400.0 | nM | - |
| CHEMBL111860 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL112126 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1650839 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL324103 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL112527 | — | IC50 | > | 10000.0 | nM | - |