Assay Detail
Functional
CHEMBL1663720
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Antiprotozoal activity against trypomastigote forms of Trypanosoma cruzi Tulahuen C2C4 expressing LacZ by alamar blue assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiprotozoal activity of N-alkoxy analogues of the trypanocidal lead compound 4,4'-bis(imidazolinylamino)diphenylamine with improved human blood-brain barrier permeability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.60 | 5.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1650072 | — | — | 1 | 5.18 |
| CHEMBL1650073 | — | — | 1 | 4.62 |
| CHEMBL1650075 | — | — | 1 | 4.52 |
| CHEMBL1650071 | — | — | 1 | 4.06 |
| CHEMBL1650070 | — | — | 1 | - |
| CHEMBL1650074 | — | — | 1 | - |
| CHEMBL1650076 | — | — | 1 | - |
| CHEMBL1650077 | — | — | 1 | - |
| CHEMBL1650078 | — | — | 1 | - |
| CHEMBL1650079 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1650072 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL1650073 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL1650075 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1650071 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL1650070 | — | IC50 | = | 136000.0 | nM | - |
| CHEMBL1650074 | — | IC50 | > | 204000.0 | nM | - |
| CHEMBL1650076 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1650077 | — | IC50 | > | 124000.0 | nM | - |
| CHEMBL1650078 | — | IC50 | > | 108000.0 | nM | - |
| CHEMBL1650079 | — | IC50 | > | 104000.0 | nM | - |