Assay Detail
Binding
CHEMBL1663858
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Inhibition of horse serum BChE after 2 mins by Ellman's reaction
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Citrusosides A-D and furanocoumarins with cholinesterase inhibitory activity from the fruit peels of Citrus hystrix.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.82 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.50 |
| CHEMBL1651089 | — | — | 1 | 4.95 |
| CHEMBL1079119 | — | — | 1 | 4.81 |
| CHEMBL448060 | ISOIMPERATORIN | — | 1 | 4.64 |
| CHEMBL1651087 | (+)-OXYPEUCEDANIN | — | 1 | 4.19 |
| CHEMBL1651084 | CITRUSOSIDE A | — | 1 | - |
| CHEMBL1651085 | CITRUSOSIDE B | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1651089 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL1079119 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL448060 | ISOIMPERATORIN | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL1651087 | (+)-OXYPEUCEDANIN | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL1651084 | CITRUSOSIDE A | IC50 | = | 376000.0 | nM | - |
| CHEMBL1651085 | CITRUSOSIDE B | IC50 | = | 339000.0 | nM | - |