Assay Detail
Functional
CHEMBL1664585
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production treated for 2 hrs before LPS challenge measured after 24 hrs by ELISA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
β-carboline alkaloids from Stellaria dichotoma var. lanceolata and their anti-inflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.87 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225304 | PIMAGEDINE | 2.0 | 1 | 5.34 |
| CHEMBL1651329 | DICHOTOMIDE X | — | 1 | 4.95 |
| CHEMBL1651328 | DICHOTOMIDE III | — | 1 | 4.76 |
| CHEMBL1651332 | — | — | 1 | 4.75 |
| CHEMBL1651331 | STELLARINES B | — | 1 | 4.73 |
| CHEMBL1651330 | STELLARINES A | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225304 | PIMAGEDINE | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1651329 | DICHOTOMIDE X | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL1651328 | DICHOTOMIDE III | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL1651332 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL1651331 | STELLARINES B | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL1651330 | STELLARINES A | IC50 | = | 19300.0 | nM | 4.71 |