Assay Detail
ADMET
CHEMBL1664604
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP2C9
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New drug-like hydroxyphenylnaphthol steroidomimetics as potent and selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of estrogen-dependent diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.34 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1650645 | — | — | 1 | 6.82 |
| CHEMBL1109 | SULFAPHENAZOLE | 4.0 | 1 | 6.60 |
| CHEMBL1650652 | — | — | 1 | 6.57 |
| CHEMBL1650654 | — | — | 1 | 5.90 |
| CHEMBL469227 | — | — | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1650645 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1109 | SULFAPHENAZOLE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1650652 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1650654 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL469227 | — | IC50 | = | 1640.0 | nM | 5.79 |