Assay Detail
Functional
CHEMBL1670311
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
6
Total Activities
5
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 9.04 | 10.09 |
| Kb | 1 | - | - |
| IC50 | 1 | 9.26 | 9.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | — | 2 | 10.09 |
| CHEMBL332897 | — | — | 1 | 9.26 |
| CHEMBL87778 | — | — | 1 | 8.86 |
| CHEMBL352257 | — | — | 1 | 8.82 |
| CHEMBL340315 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | Kd | = | 0.08128 | nM | 10.09 |
| CHEMBL332897 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL87778 | — | Kd | = | 1.38 | nM | 8.86 |
| CHEMBL352257 | — | Kd | = | 1.514 | nM | 8.82 |
| CHEMBL340315 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | Kb | = | 0.1 | nM | - |