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Evidence Snapshot

Type-1 angiotensin II receptor

CHEMBL3948 SINGLE PROTEIN Oryctolagus cuniculus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:30:31Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3948
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Type-1 angiotensin II receptor as ChEMBL target CHEMBL3948, mapped to UniProt P34976. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Type-1 angiotensin II receptor
SINGLE PROTEIN · Oryctolagus cuniculus
As of 2026-09-13
ChEMBL target ID
CHEMBL3948
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P34976
Type-1 angiotensin II receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Type-1 angiotensin II receptor matters

As of 2026-09-13

Type-1 angiotensin II receptor is reviewed as Type-1 angiotensin II receptor (UniProt P34976); the current evidence base includes 3 approved drugs, 1217 compounds, and 116 assays, with lead potency reaching pChEMBL 10.4.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 3 approved drugs, 1217 compounds, and 116 assays for this target. The dominant activity type is IC50. CHEMBL138690 is the current potency anchor at pChEMBL 10.4.

Use CHEMBL138690 as the tractability anchor when discussing potency (pChEMBL 10.4).

Activity source · ChEMBL 36 via Core Engine
3 approved pChEMBL 10.4
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Type-1 angiotensin II receptor matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P34976, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

1217
Total Compounds
116
Total Assays
3
Approved Drugs
IC50: 1318.0, KI: 6.0, EC50: 2.0, KD: 139.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL138690
 10.4 IC50 —
No preferred name
CHEMBL293511
 10.3 Kd —
No preferred name
CHEMBL416477
 10.3 Kd —
No preferred name
CHEMBL418226
 10.3 Kd —
No preferred name
CHEMBL265797
 10.3 IC50 —

Approved Drugs

Structure Compound First Approval
CANDESARTAN CILEXETIL
CHEMBL1014
 1998
LOSARTAN
CHEMBL191
 1995
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:30:31Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3948