Assay Detail
Binding
CHEMBL1670338
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to angiotensin AT1 receptor in rabbit aortic rings
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.13 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293511 | — | — | 1 | 9.70 |
| CHEMBL7550 | L-158809 | — | 1 | 9.52 |
| CHEMBL344407 | — | — | 1 | 9.15 |
| CHEMBL1667998 | — | — | 1 | 9.11 |
| CHEMBL337086 | — | — | 1 | 9.10 |
| CHEMBL442963 | — | — | 1 | 9.00 |
| CHEMBL303147 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293511 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL7550 | L-158809 | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL344407 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1667998 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL337086 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL442963 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL303147 | — | IC50 | = | 5.0 | nM | 8.30 |