Assay Detail
Binding
CHEMBL1670415
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Inhibition of ROCK1 in human THP cells assessed as inhibition of MCP1-induced cell migration
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | THP |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.85 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1667965 | — | — | 1 | 6.48 |
| CHEMBL1667967 | — | — | 1 | 6.18 |
| CHEMBL1643574 | — | — | 1 | 6.11 |
| CHEMBL1643368 | — | — | 1 | 5.30 |
| CHEMBL1667963 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1667965 | — | IC50 | = | 331.13 | nM | 6.48 |
| CHEMBL1667967 | — | IC50 | = | 660.69 | nM | 6.18 |
| CHEMBL1643574 | — | IC50 | = | 776.25 | nM | 6.11 |
| CHEMBL1643368 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL1667963 | — | IC50 | = | 6918.31 | nM | 5.16 |