Assay Detail
Functional
CHEMBL1670668
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.20 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245444 | — | — | 1 | 8.40 |
| CHEMBL1668002 | — | — | 1 | 8.30 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245444 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL1668002 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL191 | LOSARTAN | Kd | = | 12.59 | nM | 7.90 |