Assay Detail
Functional
CHEMBL1670836
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Antiproliferative activity against human Jurkat cells after 48 hrs by celltiter glo assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.04 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1668411 | — | — | 1 | 5.26 |
| CHEMBL1668417 | — | — | 1 | 5.12 |
| CHEMBL1668413 | — | — | 1 | 5.08 |
| CHEMBL1668416 | — | — | 1 | 5.06 |
| CHEMBL1668418 | — | — | 1 | 5.05 |
| CHEMBL1668412 | — | — | 1 | 5.04 |
| CHEMBL1668414 | — | — | 1 | 5.01 |
| CHEMBL1668415 | — | — | 1 | 5.01 |
| CHEMBL1668419 | — | — | 1 | 5.01 |
| CHEMBL1651523 | — | — | 1 | 4.96 |
| CHEMBL1668420 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1668411 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1668417 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL1668413 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL1668416 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL1668418 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL1668412 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL1668414 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL1668415 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL1668419 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL1651523 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1668420 | — | IC50 | = | 15400.0 | nM | 4.81 |