Assay Detail
Binding
CHEMBL1671029
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Displacement of [3H]AMPA from AMPA receptor in Sprague-Dawley rat brain synaptic membrane after 30 mins by scintillation counting
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.87 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12442 | — | — | 1 | 7.70 |
| CHEMBL1669239 | — | — | 1 | 5.39 |
| CHEMBL1669240 | — | — | 1 | 4.51 |
| CHEMBL421402 | — | — | 1 | - |
| CHEMBL197633 | — | — | 1 | - |
| CHEMBL199181 | — | — | 1 | - |
| CHEMBL1669237 | — | — | 1 | - |
| CHEMBL1669238 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12442 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL1669239 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL1669240 | — | Ki | = | 31000.0 | nM | 4.51 |
| CHEMBL421402 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL197633 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL199181 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1669237 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1669238 | — | Ki | > | 100000.0 | nM | - |