Compound Detail
CHEMBL1669240
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Basic Information
| ChEMBL ID | CHEMBL1669240 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JJXSBQZTZGVXPH-WISUUJSJSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
216.2
MW (Da)
-0.74
ALogP
5
HBA
3
HBD
122.2
PSA (Ų)
0.57
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 5.29
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor CHEMBL1907608 | Ki | 5.29 | 5.29 | 5100.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 4.51 | 4.38 | 31000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor | Ki | = | 5100.0 | nM | 5.29 | Displacement of [3H]CGP 39653 from NMDA receptor in Sprague-Dawley rat brain syn... | 21220180 |
| Unchecked | Ki | = | 31000.0 | nM | 4.51 | Displacement of [3H]AMPA from AMPA receptor in Sprague-Dawley rat brain synaptic... | 21220180 |
| Unchecked | Ki | = | 56000.0 | nM | 4.25 | Displacement of [3H]KAIN from kainate receptor in Sprague-Dawley rat brain synap... | 21220180 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21220180 | 10.1016/j.ejmech.2010.12.020 | Unchecked | 2 |
| 21220180 | 10.1016/j.ejmech.2010.12.020 | Glutamate NMDA receptor | 1 |
Data from ChEMBL 36 via Core Engine