Assay Detail
Binding
CHEMBL1671028
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CGP 39653 from NMDA receptor in Sprague-Dawley rat brain synaptic membrane after 60 mins by scintillation counting
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.56 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197633 | — | — | 1 | 6.68 |
| CHEMBL421402 | — | — | 1 | 6.43 |
| CHEMBL199181 | — | — | 1 | 6.02 |
| CHEMBL1669239 | — | — | 1 | 5.52 |
| CHEMBL1669240 | — | — | 1 | 5.29 |
| CHEMBL1669237 | — | — | 1 | 4.75 |
| CHEMBL1669238 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197633 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL421402 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL199181 | — | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL1669239 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL1669240 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL1669237 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL1669238 | — | Ki | = | 60000.0 | nM | 4.22 |